Ami’s metastasis paper comes out in PNAS today. In this study, we asked where tumor cell dissemination from. We thought the action would be at the tumor’s edge. But instead we find a role for cancer cells in the necrotic core: zones of intense cell death within tumors. Along the way, we identify a tumor-secreted protein expressed deep inside the tumor involved in regulating necrosis, CTC dissemination and metastasis. Read the paper to find out more.
Link to Hutch Center News article.
Link to Charles River Webinar on in vivo modeling of breast tumor dissemination.
Link to Hutch Science Spotlight. Thank you to David Sokolov for writing this piece!