Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis
Greenwood E, Wrenn ED, Cheung KJ.
Dev Cell. 2017 Feb 27;40(4):328-330. doi: 10.1016/j.devcel.2017.02.014.
Abstract
The properties of stem cells that participate in mammary gland branching morphogenesis remain contested. Reporting in Nature, Scheele et al. (2017) establish a model for post-pubertal mammary branching morphogenesis in which position-dependent, lineage-restricted stem cells undergo cell mixing in order to contribute to long-term growth.