Selected Publications
Cheung lab members are bolded.
Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
Yamamoto A, Huang Y, Krajina BA, McBirney M, Doak AE, Qu S, Wang CL, Haffner MC, Cheung KJ.
PNAS 2023; 120 (10) e2214888120. Online ahead of print.
Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters
Yamamoto A*, Doak AE*, Cheung KJ.
* co-first authors
Annu Rev Pathol. 2022 Oct 7. Online ahead of print.
Mechanisms of breast cancer metastasis
Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K.
Clin Exp Metastasis. 2022 Feb;39(1):117-137.
Dynamic contrast-enhanced breast MRI features correlate with invasive breast cancer angiogenesis
Xiao J, Rahbar H, Hippe DS, Rendi MH, Parker EU, Shekar N, Hirano M, Cheung KJ, Partridge SC.
NPJ Breast Cancer. 2021 Apr 16;7(1):42. doi: 10.1038/s41523-021-00247-3.
Collective metastasis: coordinating the multicellular voyage
Wrenn E, Huang Y, Cheung K.
Clin Exp Metastasis. 2021 Aug;38(4):373-399.
Optimal, Large-Scale Propagation of Mouse Mammary Tumor Organoids
Wrenn ED, Moore BM, Greenwood E, McBirney M, Cheung KJ.
J Mammary Gland Biol Neoplasia. 2020 Dec;25(4):337-350.
Regulation of Collective Metastasis by Nanolumenal Signaling
Wrenn ED, Yamamoto A, Moore BM, Huang Y, McBirney M, Thomas AJ, Greenwood E, Rabena YF, Rahbar H, Partridge SC, Cheung KJ.
Cell. 2020 Oct 15;183(2):395-410.e19.
Organotypic culture assays for murine and human primary and metastatic-site tumors
Padmanaban V, Grasset EM, Neumann NM, Fraser AK, Henriet E, Matsui W, Tran PT, Cheung KJ, Georgess D, Ewald AJ.
Nature Protocols. 2020 Aug;15(8):2413-2442.
Between-tumor and within-tumor heterogeneity in invasive potential
Padmanaban V, Tsehay Y, Cheung KJ, Ewald AJ, Bader JS.
PLoS Comput Biol. 2020 Jan 21;16(1):e1007464.
Double Trouble: Contralateral Breast Cancer Risk Management in the Modern Era
Cheung KJ, Davidson NE.
J Natl Cancer Inst. 2019 Jul 1;111(7):641-643.
FoxP1 Tspans Quiescence and Activation of Mammary Stem Cells
Wrenn ED, Cheung KJ.
Dev Cell. 2018 Dec 3;47(5):539-540.
Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis
Greenwood E, Wrenn ED, Cheung KJ.
Dev Cell. 2017 Feb 27;40(4):328-330.
A collective route to metastasis: Seeding by tumor cell clusters
Cheung KJ, Ewald AJ.
Science. 2016 Apr 8;352(6282):167-9.
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters
Cheung KJ,* Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ*.
* co-corresponding authors
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63.
Some of Kevin’s Papers Before Opening the Lab
3D culture assays of murine mammary branching morphogenesis and epithelial invasion
Nguyen-Ngoc KV, Shamir ER, Huebner RJ, Beck JN, Cheung KJ, Ewald AJ.
Methods Mol Biol. 2015;1189:135-62.
Illuminating breast cancer invasion: diverse roles for cell-cell interactions
Cheung KJ, Ewald AJ.
Curr Opin Cell Biol. 2014 Oct;30:99-111.
Invasive leader cells: metastatic oncotarget
Cheung KJ, Ewald AJ.
Oncotarget. 2014 Mar 30;5(6):1390-1.
Collective invasion in breast cancer requires a conserved basal epithelial program
Cheung KJ, Gabrielson E, Werb Z, Ewald AJ.
Cell. 2013 Dec 19;155(7):1639-51.
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium
Nguyen-Ngoc KV*, Cheung KJ*, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ.
* co-first authors
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2595-604.
Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium
Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M.
J Cell Sci. 2012 Jun 1;125(Pt 11):2638-54.
Cellular mechanisms regulating epithelial morphogenesis and cancer invasion
Gray RS, Cheung KJ, Ewald AJ.
Curr Opin Cell Biol. 2010 Oct;22(5):640-50.
Therapeutic potential of targeting haploinsufficient genes in cancer
Cheung KJ, Ebert BL.
Pediatr Blood Cancer. 2009 Aug;53(2):131-2.
Concurrent invasive ductal carcinoma and chronic lymphocytic leukemia manifesting as a collision tumor in breast
Cheung KJ, Tam W, Chuang E, Osborne MP.
Breast J. 2007 Jul-Aug;13(4):413-7.
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity
Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM.
Cell Metab. 2007 Feb;5(2):115-28.
Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation
Selinger DW, Saxena RM, Cheung KJ, Church GM, Rosenow C.
Genome Res. 2003 Feb;13(2):216-23.
A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli
Cheung KJ, Badarinarayana V, Selinger DW, Janse D, Church GM.
Genome Res. 2003 Feb;13(2):206-15.
RNA expression analysis using a 30 base pair resolution Escherichia coli genome array
Selinger DW, Cheung KJ, Mei R, Johansson EM, Richmond CS, Blattner FR, Lockhart DJ, Church GM.
Nat Biotechnol. 2000 Dec;18(12):1262-8.